It has been evident that the insular cortex (IC) is involved in formation of nicotine addiction. However, its neural mechanisms remain largely unclear. Therefore, we have recently investigated how activation of nicotinic acetylcholine receptors (nAChRs) affects synaptic activities such as synaptic transmission and plasticity in layer 3, 5 and 6 (L3, L5 and L6, respectively) pyramidal cells (PCs) of the IC in mice. Furthermore, we investigated which cell types have functional nicotinic receptors in L3, L5 and L6 of the IC. We have found that activation
of nicotinic receptors layer-dependently modulates synaptic transmission and plasticity in L3, L5 and L6 PCs of the mouse IC. In this short review, I describe our experimental evidence which may contribute to neuronal mechanisms for addiction to tobacco smoking.
Citation: Toyoda H. 2018. Layer-Dependent Modulation of Mouse Insular Synaptic Activities by Nicotinic Acetylcholine Receptors. J Reward Defic Syndr Addict Sci 4(1): 9-12.