I present two alternatives to simple gene frequency in testing for the potential association between different genes and polygenic traits. These are testing for molecular heterosis and testing for hidden variables such as the mother’s age at the birth of her first child. They have the potential to identify genes that may have appeared to be unassociated with the phenotype and to increase the percent of the variance for other genes. With this added help an algorithm evaluating the additive effect of the 10 to 20 genes with the greatest percent of the variance may allow genetic testing for susceptibility to the RDS spectrum and other polygenic disorders.

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