Volume 3 Issue 2

Pharmacological Inhibition of Brain Fatty Acid Binding Protein Reduces Ethanol Consumption in Mice

Antonio Figueiredo, John Hamilton, Matthew Marion, Kenneth Blum, Martin Kaczocha, et al.
The endocannabinoid (eCB) system is involved in a wide range of behavioral disorders including alcoholism. Inhibition of fatty acid amide hydrolase (FAAH), the principal enzyme that degrades the eCB anandamide (AEA), which
enhances AEA levels in the brain, significantly increases ethanol consumption and preference.

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