Physical exercise offers an epigenetic propensity that holds benefits with several health domains, particularly for children and adolescents. Yet, it is only recently that that regular exercise has begun to be construed as a positive epigenetic mechanism to modify the genome-wide DNA methylation pattern in humans . Epigenetics is emerging a science that examines processes-beyond DNA sequence alteration-producing heritable characteristics  with exercise regimes, with or without dietary restrictions, as essential epigenetic interventions [3, 4]. Nevertheless, Exercise and nutrition are synergistic in mitigating disorder states with exercise releasing exosomes that contain miRNAs. Nutrition/vitamins B6 and B12 regulate the metabolism of homocysteine, an epigenetic byproduct of DNA/RNA/protein methylation . This type of development ushers in, amongst other aspects, the fact that DNA methylation induces modification of gene expression without causing any the nucleotide sequence. In the context of health problems associated with obesity, Ursu et al. 
Citation: Archer T. 2015. Epigenetic Changes Induced by Exercise. J Reward Defic Syndr Addict Sci 1(2): 71-74.